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Raf Tangmere in 100 Objects: The History of a Battle of Britain Fighter Base

為了解決Incident的問題，作者Hillier, Mark 這樣論述：

On 16 November 1916, Lieutenant Geoffrey Dorman took off from Shoreham in a Royal Aircraft Factory FE2b with the intention of heading West along the South Coast to the airfield at Gosport. Not long into the flight, however, a dense sea fog formed and as his engine was also 'misbehaving', Dorman d

ecided 'it would be best to try and land'. Spotting a suitable area of farmland, Lieutenant Dorman put his aircraft down near the West Sussex village of Tangmere. Evidently aware of what he had stumbled across, Dorman's subsequent report on the incident included a suggestion that the site would be e

minently suitable for an aerodrome. Within twelve months, construction had started - and so was born the legend of RAF Tangmere. Over the years that followed, Tangmere became one of the best known and strategically most important fighter stations in the United Kingdom. From its connections with the

highly-polished air displays given at various RAF pageants in the 1920s and 1930s, through to numerous royal visits, or for its role in the post-war record-breaking speed flights or as a Cold War air-sea rescue base, Tangmere was a vital part of the nation's defenses. It is, however, for its service

on the front line in the Second World War that Tangmere is best remembered. Not only was the airfield itself bombed and blitzed, its aircraft and pilots also found themselves in the thick of the fighting in the Battle of Britain, before turning to an increasingly offensive role whilst led by Wing C

ommander Douglas Bader. Operation Jubilee, the Combined Operations raid on Dieppe, and the D-Day landings in 1944 all required RAF Tangmere to play its part. As well as overt offensive sorties, Tangmere was involved in the secretive world of covert warfare, when, during the full moon periods, 'A' Fl

ight of 161 (Special Duties) Squadron would move its Lysanders forward to Tangmere. As well as delivering SOE agents, wireless operators, wireless equipment and weapons to assist the Resistance, these aircraft often returned with agents, VIPs and even Allied escapers and evaders. In this highly-illu

strated publication, the renowned aviation historian and author Mark Hillier explores the development and role of RAF Tangmere from 1916 until its closure in 1970, along with some of the fascinating individuals associated with it, through an intriguing collection of 100 objects.

Incident進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Incident的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Computer Forensics: Computer Crime Scene Investigation

為了解決Incident的問題，作者Vacca, John R. 這樣論述：

Despite efforts to safeguard sensitive data and networks, organizations face an ever-growing threat of cyber crime and security violations. These attacks can occur internally as well as from an external source, and include fraud, copyright infringement, and stolen data. This computer forensics and i

ncident response book provides an organization's internal computer security specialists with a legal method for handling computer misuse as well as a means for securing sensitive data and identifying compromised systems, ultimately saving the organization the high cost of hiring an outside team of c

omputer forensic investigators. This updated Third Edition includes a comprehensive introduction to computer forensics investigative techniques and provides the knowledge and skills required to conduct a computer forensics investigation from initial discovery to completion. This book also provides t

he details for an organization's Computer Incident Response Team (CIRT); to collect, manage, and record digital evidence; and to leverage powerful software tools and techniques to uncover hidden or deleted information. Key topics include: Responding to incidents and investigating computer crime, con

ducting and managing an investigation, performing disk-based analysis, investigating information-hiding techniques, examining e-mail, tracing internet access, searching memory in real-time, and the forensics challenge competition.

資訊安全事件管理平台的自動化聯合防護阻擋機制之研究

為了解決Incident的問題，作者劉鍵毅 這樣論述：

隨著台灣資通安全意識提升，國內許多企業、法人或公務機關，逐漸重視資訊安全的防護，導入資訊安全事件管理平台，使網路活動及日誌可視化，並集中於同一平台上，讓資安管理人員能直接在SIEM平台上直接看見許多設備的日誌，平時除了能主動查找異常日誌外，也能被動地建立規則條件及門檻值（Threshold）使日誌被規則關聯。在有了告警功能後，管理者便可以一目了然的看見告警的原因，再經由人工判斷，判斷是否需要將該事件的IP新增到具有阻擋功能之設備進行阻擋，或向具阻擋功能之資安設備管理者申請阻擋。本研究將實作開發自動化聯防阻擋程式，並在資訊安全事件管理平台上建立相關規則，並利用模擬真實事件發生時的日誌，在資訊安

全事件管理平台上模擬出設備日誌，將資訊安全事件管理平台所觸發相關規則之事件IP，透過自動化阻擋程式，將IP送至入侵偵測防禦系統（Intrusion Prevention System, IPS）黑名單進行阻擋，以符合自動化阻擋機制，並將阻擋程式之日誌送至SIEM進行監控，最後將整體機制呈現於結果。