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Renzo Piano Box I: The Whitney Museum, New York; The Shard, London; The Stravos Niarchos Foundation, Athens

為了解決b box的問題，作者 這樣論述：

"One of the great beauties of architecture is that each time, it is like life starting again." -Renzo PianoThe Renzo Piano Box is a set of highly collectible volumes by star architect Renzo Piano. The box is an elegantly designed slipcase that envelops three (11" x 11") gorgeously printed paperbo

und books, each showcasing one of the great architect's iconic buildings: The Whitney Museum, in New York; The Shard in London; and the Stravos Niarchos Foundation in Athens. Callaway plans to publish a box every season, each with three different titles, and to bring to the many readers and fans of

Piano's astonishing architectural masterpieces his entire series of collected works.The Whitney Museum, New York In 2015, the new home of the Whitney Museum opened to the public in downtown Manhattan's Meatpacking District, substantially enlarging the Whitney's exhibition and programming space. The

new building includes some 4,650 sq. meters of gallery space distributed over the fifth, sixth and seventh levels. The fifth level boasting a 1670 sq. meters, column-free gallery - making it the largest open-plan museum gallery in New York City. The book includes many architectural drawings and the

text at the end of the book provides the reader with a "behind the scenes" view. A conception of the museum that starts from the work of art to arrive at the architectural project. A journey that takes the reader through time and space during its realization.The Shard, London: The London Bridge Towe

r, the tallest building in Europe, also known as the Shard, is a 72-storey, mixed-use tower located beside London Bridge Station on the south bank of the river Thames. A mix of uses - residential, offices and retail - creates a building that is in use 24 hours a day. The slender, pyramidal form of t

he tower was determined by its suitability to the mix of large floor plates at the bottom for offices; restaurants, public spaces and a hotel located in the middle; private apartments at the top of the building. The final floors accommodate a public viewing gallery, 240 m above street level. This ar

rangement of functions also allows the tower to taper off and disappear into the sky, and makes the building look like a shard of glass, a particularly important detail for architect Renzo Piano given the building's prominence on the London skyline. The Stravos Niarchos Cultural Centre, Athens The S

tavros Niarchos Cultural Centre was constructed in Kallithea, 4 km south of central Athens. An important cultural and educational project, the site comprises the National Library of Greece and the Greek National Opera in a 170,000 square meter landscaped park. Previously a parking lot left over from

the 2004 Olympic Games, once upon a time the site of a racetrack, this new Renzo Piano project restores the site's lost connections with the city and the sea.

b box進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決b box的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

The Shadow’s Oracle: Deck of 30 Cards and Guidebook

為了解決b box的問題，作者Marion B. 這樣論述：

Intuitive, sober and fascinating, this oracle invites you to explore the unknown parts of yourself and to go over your limiting thoughts. It will become your ally to take the different steps of your personal path.There is no day without night, no shadow without light. This box contains 30 cards of c

aptivating guidance that pierce the shadow veil and shine a light inside of you. Its author, passionate and fascinated by the esoteric world, hands you a unique oracle made of black and white portraits whose deep looks will push you to overcome your limits. Its guidebook will lead you through this j

ourney and make you prevail on stalemates. Go off to explore your new being, it is time for rebirth! Marion B. has been passionate about art and esotericism since childhood, having been raised by a family willing to foster a curiosity for the occult. Marion awarded with the Prix Claude Nougaro in

2016 in the cartoon category and after graduating in fine arts has developed several projects from cartoon to decks and collections.

探討數位科技導入餐飲服務業對於消費者服務體驗之影響

為了解決b box的問題，作者張雅涵 這樣論述：

數位革命成為一股強大的變革力量，然而大多數的研究討論上亦聚焦於導入數位科技對廠商之優勢和效益，卻少以從消費者視角深入地探討心理感受。因此，本研究首先透過文獻綜整分析針對餐飲業將不同數位科技進行分類，並整理說明這些不同類型數位科技之特性，進而運用消費者深度訪談分析這些科技運用對於消費者接觸時所產生之感受和體驗，欲歸納出消費者在面對各類型餐飲數位科技服務的不同服務情境所產生的可能正反面感受。研究結果發現在服務前、中，主要優點是省時、便利、舒適自在。在服務後，其主要優點有輕便方便、舒適自在、自主性。再者，個人的心理也產生截然不同的缺點，在服務前，主要缺點分別為:系統介面未優化、缺乏溫度真實感、服務

介面制式化、疏遠性。而在服務中的有:缺乏溫度真實感、使用介面不流暢、功能單一化。至於在服務後，強迫不適感、時差性、資料安全疑慮盜刷風險上述三個為主要缺點。最後，本研究貢獻方面，在實務管理意涵上，期望透過這些結果能供業者在導入數位科技於服務流程中之商業價值，以提供餐飲業者在擬定服務創新策略時之參考。