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End Game: Does Israel Have a Plan?

為了解決Remain的問題，作者Sachs, Natan 這樣論述：

How Israelis envision and plan for the future of their countryDoes Israel have a plan? What does the country want to look like in 10 or 20 years? What borders does it hope to have? Will the West Bank or the Gaza Strip be part of it? Will the Palestinians residing the territories be granted citizensh

ip and become Israeli citizens? Does the country as a whole even know what it wants, what its goals are, or how to achieve them?Israel faces a fundamental question, a "trilemma." It can choose only two of three different goals many Israelis hold dear: to maintain control over the West Bank, with its

strategic and religious significance to Israel; to retain a clear Jewish majority, the goal of the Zionist movement that founded the state; or to remain a democracy, with full voting rights for all citizens.This trilemma has caused world leaders and publics, Israel-supporters and critics, to wonder

aloud time and again: what does Israel want? If it wishes to maintain its Jewish and democratic character, surely it must separate from the West Bank and its population; why then does Israel keep building in Israeli settlements in the West Bank, making such separation all the more difficult? And if

it plans to retain control over the West Bank, is it really willing to give up on either its Jewish nature or its democracy?End Game attempts to solve the puzzle of why the Israeli strategic vision seems so elusive to many foreigners and Israelis alike. It explores how Israelis' beliefs about their

future are formed and how their visions are translated into policy, focusing on three factors in depth: the role of security concerns, ideology, and domestic political constraints that combine to shape Israel's strategic posture.The book contrasts the full range of views in Israel over the future o

f the West Bank, from supporters of a bi-national state or confederacy on the left, to supporters of a "one state" on the far right of the political spectrum. It pays particular attention to the worldview of the political center-right, led by Prime Minister Benjamin Netanyahu, a conservative, risk-a

verse and "anti-solutionist" approach to the problem. This worldview, following decades of precedent, rejects the need for a full-fledged strategic "solution" to the problem, leading to widespread confusion over Israel's goals. The book analyses and critiques this approach, arguing forcefully for en

ding Israeli indecision over the future of the land and in favor of partition and, eventually, peace. Dr. Natan Sachs is a fellow in the Center for Middle East Policy at the Brookings Institution. His research focuses on Israel’s foreign policy, its domestic politics, and on U.S.-Israeli relations

. Before joining Brookings, Sachs was a Hewlett Fellow at Stanford’s Center on Democracy, Development and the Rule of Law, a Fulbright Fellow in Indonesia, and a Visiting Fellow at Tel Aviv University’s Dayan Center for Middle Eastern and African Studies.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Remain的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Both Sides of the Wire - Disaster at Dawn: Somme 1916: Preliminaries and First Moves

為了解決Remain的問題，作者Cave, Nigel/ Sheldon, Jack 這樣論述：

Both Sides of the Wire is the first in a new series of battlefield guides that looks at the fighting on the Western Front, chiefly in the sectors in which the British Expeditionary Force was engaged. In these books, Nigel Cave and Jack Sheldon will look at engagements from both the allied and Ger

man perspective; at the end of each chapter there will be a tour section so that readers can place themselves in the best vantage points to follow the action that is described on the ground and which is directly related to the narrative account that will form the bulk of each chapter. This book deal

s with the Somme up to and including the first day or two of the infantry assault on 1 July. In addition to the familiar British sector, the authors intend to cover those parts of the Somme battlefield that were (largely) fought over by the French. Although there is much to see of the 'French' Secto

r, it is generally poorly served by published guides despite the fact that there are numerous signs of the Great War of the ground, many accessible to the public. With the concentration on 1st July and the subsequent months, there is relatively little about what happened on the Somme from the establ

ishment of the line there in October 1914 to the summer 1916 offensive. For example, this involved extensive mine warfare, of which very few traces remain, but for which there is excellent contemporary mapping and some useful accounts. Because of the considerable amount of literature already availab

le on the British sector of the Somme, the authors will be concentrating on particular aspects - areas selected include: Gommecourt (56th London Division); Serre (the French attacks of June 1915); the Heidenkopf; raids prior to I July around Beaumont Hamel; the Schwaben Redoubt, the German defence p

lan and what happened on the day; the Glory Hole and the fighting there from December 1914; the area around King George's Hill, near Fricourt; the attacks and counter attacks at Montauban on 1 - 3 July 1916; a very successful limited German assault at Feuilleres in January 1916; the line at Dompierr

e and Fey, in particular mine warfare (and also some coverage of the brief tenure of the line in this area by the British in the autumn of 1915). The book is aimed at anyone with an interest in the war, in the Somme in particular and, whilst acting as a guide, it will also be of value to those who c

annot get to the Somme themselves, with the authors aiming at a more balanced understanding of what happened and explaining the outcomes at the various locations.

教練型領導組織承諾的關係:以組織創新活力為中介變項

為了解決Remain的問題，作者賴世耕 這樣論述：

教練型領導是通過鼓勵、指導、授權等方式樹立工作目標，最終實現領導者和員工之間相互促進以及共同發展。透過提高組織創新活力，來提高組織承諾，使員工達到對企業有緊密的關係，並且提高創新活力，以利組織面對環境改變越來越快速的問題。本研究之搜取樣本方法使用便利抽樣方式，而研究對象為台灣企業之員工，須在公司滿3個月以上工作經驗，並具有團隊經驗，以網路問卷發放，共回收452份問卷，刪除無效問卷後共409份，有效問卷之回收率為90.48%。在統計數據顯示，假設一為教練型領導對整體組織承諾具有顯著正向影響(β=.712 , p < .001)，故假設一成立。假設二教練型領導對整體組織創新活力具有顯著正向影響(

β=.749 , p < .001)，故假設二的推論成立。假設三組織創新活力對整體組織承諾具有顯著正向影響(β=.846 , p < .001)，假設三的推論成立。假設四組織創新活力中介教練型領導與組織承諾之間在加入組織創新活力的中介變項後，教練型領導對組織承諾的影響力下降(β= .712 , p < .001、β= .183 , p < .001)，故假設四成立。根據上述的假設成立給予實務上的建議，首先，在現今大數據時代的來臨，若組織內部的領導者具有教練型領導風格，可以帶給員工更高的組織承諾；在面對需要快速創新的產業與組織，教練型領導能夠促進組織創新活力，是組織面對創新更有動能；在組織中的組

織創新活力的程度越高，會更吸引組織內部的成員提高歸屬感與承諾；在了解組織創新活力中介於教練型領導與組織承諾之間，可以更能夠了解，組織內部員工對於領導者與組織需要能夠帶來協助與好的溝通才有辦法讓員工有所歸屬。